Chinese Academy of Sciences Hefei Institute of ion mobility spectrum new technology research progress

【Chinese instrument network instrument research and development】 Recently, the Institute of Spectrometry and Mass Spectrometry of the Center of Medical Physics and Technology of the Chinese Academy of Sciences, Hefei Institute of Material Science has made progress in the research of new technologies in ion mobility spectrometry. The researchers developed a new method for the counter ion migration spectrum of Hadamard transform. The simultaneous enhancement of resolution and sensitivity of the ion mobility spectrum is achieved.

Enhanced ion mobility spectrum with both resolution and sensitivity

Resolution and sensitivity are important parameters of the ion mobility spectrum. The resolution reflects the separation ability of the migration spectrum, and the sensitivity or signal-to-noise ratio reflects the detection limit of the migration spectrum. Resolution and sensitivity often limit each other: it is difficult to maintain the sensitivity of the resolution, and to increase the sensitivity is to sacrifice the resolution. At the same time, enhanced resolution and sensitivity are the difficulties in the study of ion mobility spectrometry.

It has been shown that the spectrum of the counter-ion migration similar to the absorption spectrum can improve the resolution of the migration spectrum, and the Hadamard transform ion mobility spectrum can improve the signal-to-noise ratio or sensitivity of the migration spectrum. To this end, the researchers of the Institute of Spectral-Mass Spectrometry developed the Hadamard Transform Counter-Ion Mobility Spectroscopy (MHT-IIMS) on the basis of previous studies of Hadamard transform ion mobility spectroscopy and achieved ion mobility spectrum resolution and sensitivity. At the same time enhance. Compared with the conventional ion mobility spectrum, the resolution of the migration spectrum was increased by 65% ​​and 44%, and the signal-to-noise ratio was increased by 290% and 490%, respectively, in the detection of carbon tetrachloride and chloroform. This technology provides a new technical solution for high resolution and high sensitivity detection of ion mobility spectrum.

Related research results were published in the Journal of the American Society for Mass Spectrometry.

(Original Title: Hefei Research Institute, Ion Migration Spectrometry, New Technology Research Progress)